Special Considerations for Patient Population Cases

Patient 1: 82-year-old male presenting with cognitive decline. He had always been a very active individual. Over the past year, he has become less active in the community. Previously, he played cribbage weekly with friends at the local senior center but has been struggling with the math involved with the game and no longer attends the weekly card game. He had also volunteered as a crossing guard for the local public school. He quit doing that after he took the wrong turn to get home and drove around the town feeling lost. He acknowledges he is sensitive to this and can be irritable towards his children when they bring up these concerns. He was diagnosed with mild neurocognitive disorder after completing neuropsychological testing. Of the following medications, which would be the most appropriate to prescribe? Explain why you chose this medication. What would be the dosing schedule for this patient? Provide education to the patient and review risks, benefits, and potential side effects of the medication. In addition, explain why the other medications listed are not appropriate for this patient. Med List: lorazepam, olanzapine, memantine
Patient 2: 76-year-old female who recently moved from her home to an assisted living. After 1 week of moving in, she has become extremely confused. Staff have attempted to re-orient her, and she struggles to focus on what they are saying. She is only oriented to self. She has become very agitated and has even thrown breakable objects in her room. Her family is concerned stating she is out of it. The PCP ordered labs and UA. Labs are unremarkable outside of mild leukocytosis and positive dipstick analysis for nitrite and red blood cells. Med List: valproate, alprazolam, trimethoprim
Patient 3: A 33-year-old female that is 6 weeks postpartum. She presents with depressed mood, sadness, easily emotional, difficulties with sleep even when the infant is sleeping. She has lost weight and has a poor appetite. You note psychomotor retardation. She has limited interests in hobbies or bonding with the infant. Her partner is concerned and reports she is typically active and bubbly and enjoys the outdoors. She is diagnosed with major depressive disorder, with postpartum onset. She denies suicidal ideation, homicidal ideation, or infanticidal ideation. No psychotic symptoms are present. She is nursing the infant and wants to continue this hoping it will assist with bonding with the infant. Med List: lithium, paroxetine, sertraline
Patient 4: 10-year-old male who comes in with his father. He has been diagnosed with generalized anxiety disorder. He has constant worries that he cannot control. He feels nervous and tense. He is easily irritable. He struggles to settle down or relax. He is also quite fidgety and restless. He and his father are interested in medications to manage these symptoms. Med List: quetiapine, duloxetine, fluoxetine
Patient 5: 27-year-old male with a diagnosis of schizophrenia. He has been hospitalized three (3) times in the past 1 year due to symptoms. When symptomatic, he becomes disorganized and paranoid. He will respond to auditory hallucinations. He will scream out at night after seeing a shadow in his room. He has delusions that the CIA is poisoning food and will not eat for multiple days. He has unintentionally hurt his mother after slapping food out of her hand, as he did not want her to ingest the poisoned food. Symptoms are treated very well with paliperidone, but he struggles to remember to take it. Med List: paliperidone palmitate, clozapine, lamotrigine
The Assignment (45 pages)
Construct a paper concerning your assigned vulnerable population patient case. In your paper include the following:
Determine which medication would be most appropriate to prescribe from the assigned vulnerable population patient case medication choices.
Explain your rationale for choosing this medication. Explain why the other medications listed are not appropriate for this patient.
Explain the dosing schedule for the specific patient including the therapeutic endpoint.
Provide necessary education to the patient to review risks, benefits, and potential side effects of the medication.
Describe any necessary labs or additional diagnostics needed prior to prescribing this medication.
Explain how you might monitor efficacy or side effects of the medication.
Include any additional collaboration or education to others that would be necessary for this patient. Consider family members, home health care, primary care providers, etc.
What would you need to include in your assessment for a patient who may become nonadherent with your prescribing plan for your scenario? What are alternative treatment solutions based upon how you assessed? Describe your new treatment plan.

Full Answer Section

      Why Other Medications Are Not Appropriate:
  • Lorazepam: A benzodiazepine, is primarily used for anxiety and insomnia. While it may temporarily alleviate agitation, it can worsen cognitive impairment and increase the risk of falls in elderly patients.
  • Olanzapine: An atypical antipsychotic, is indicated for the treatment of schizophrenia and bipolar disorder. It is not approved for the treatment of cognitive impairment and carries a high risk of metabolic side effects in the elderly.

Dosing Schedule:

The typical starting dose of memantine is 5 mg daily for one week, then increased to 10 mg daily for one week. The maintenance dose is usually 20 mg daily, administered in divided doses or as a once-daily extended-release formulation.

Patient Education:

  • Benefits: Memantine may help improve memory, thinking, and daily living activities.
  • Risks: Common side effects include dizziness, headache, constipation, and confusion. Less common but serious side effects include hallucinations and agitation.
  • Administration: Explain how to take the medication as prescribed.
  • Monitoring: Inform the patient about the importance of regular follow-up appointments to monitor the medication's effectiveness and to check for side effects.
  • Safety Precautions: Advise the patient to avoid driving or operating heavy machinery if experiencing dizziness or confusion.

Additional Considerations:

  • Caregiver Involvement: Educate the caregiver about the patient's condition and the importance of providing a safe and supportive environment.
  • Safety Measures: Implement safety measures at home, such as removing obstacles and installing grab bars.
  • Support Groups: Encourage the patient and caregiver to attend support groups for individuals with dementia.

Non-Adherence Assessment:

To assess non-adherence, it is important to:

  • Monitor medication levels through regular blood tests.
  • Assess patient and caregiver understanding of the medication regimen.
  • Observe for signs of medication side effects that might lead to non-adherence.
  • Use medication adherence tools, such as pill counts or electronic monitoring.

Alternative Treatment:

If the patient becomes non-adherent or if memantine is ineffective, other options to consider include:

  • Acetylcholinesterase inhibitors: Donepezil, rivastigmine, or galantamine may be beneficial for mild to moderate Alzheimer's disease.
  • Non-pharmacological interventions: Cognitive stimulation therapy, physical activity, and social engagement can help improve cognitive function and quality of life.
 

Sample Answer

     

Patient 1: 82-year-old Male with Mild Neurocognitive Disorder

Medication Choice: Memantine

Rationale:

Memantine is a NMDA receptor antagonist indicated for the treatment of moderate to severe Alzheimer's disease and moderate to severe vascular dementia. While the patient has mild neurocognitive disorder, it is often difficult to differentiate between mild Alzheimer's disease and mild vascular dementia. Memantine has been shown to improve cognition and global function in patients with mild to moderate Alzheimer's disease.