COVID-related molecular evolution analysis of the Human Gene ACE-2
- Background reading
The 1000 Genomes Project Consortium. 2015. A global reference for human genetic variation. Nature 526: 68-74.
Danecek P, Auton A, Abecasis G, Albers CA, Banks E, DePristo MA, Handsaker RE, Lunter G, Marth GT, Sherry ST, McVean G, Durbin R, 1000 Genomes Project Analysis Group. 2011. The variant call format and VCFtools. Bioinformatics App Note 27: 2156-2158.
Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J-C, Turner AJ, Raizada MK, Grant MB, Oudit GY. 2020. Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System. Circulation Research, 126(10):1456-1474
Hoffmann M, et al. 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181(2):271-280.e8
David A, Khanna T, Beykou M, Hanna G, Sternberg MJE. [Preprint]. Structure, function and variants analysis of the androgen-regulated TMPRSS2, a drug target candidate for COVID-19 infection. bioRxiv, accessed 10SEP20, DOI: 10.1101/2020.05.26.116608
Sriram K, Insel P, Loomba R. May 14, 2020. What is the ACE2 receptor, how is it connected to coronavirus and why might it be key to treating COVID-19? The experts explain. The Conversation.
http://www.internationalgenome.org/home (Links to an external site.) .
https://www.illumina.com/company/news-center/feature-articles/illumina-to-sequence-genomes-for-new-uk-wide-covid19-study.html (Links to an external site.)
Question 1.1. What is the 1000 genomes project?
Question 1.2. What are the super populations and sub-populations that contributed genomic DNA to the 1000 genomes project?
Question 1.3. Why are the ACE2 and TMPRSS2 human genes of interest when it comes to understanding the severity of covid infection?