What is your name of your therapeutic target?
What stage of atherosclerosis does your candidate influence? (1 mark)
How does your chosen candidate influence the progression of atherosclerosis? What is the mechanism behind its action? (6 marks)
How will you target your candidate? (3 marks)
Note: Do not exceed the space provided to answer each question. Do not change formatting, font, text size of this document. Up to 6 references can be cited and listed on a separate page.
Reading list
Gurung, A. B., & Bhattacharjee, A. (2018). Impact of tyrosine nitration at positions Tyr307 and Tyr335 on structural dynamics of Lipoprotein-associated phospholipase A2–A therapeutically important cardiovascular biomarker for atherosclerosis. International journal of biological macromolecules, 107(1), 1956-1964.
Gomez-Puerta, J. A., & Mócsai, A. (2013). Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Current topics in medicinal chemistry, 13(6), 760–773. Zeng, L., Mathew, A.V., Byun, J., Atkins, K.B., Brosius, F.C. and
Pennathur, S. (2018). Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease–accelerated atherosclerosis. Journal of Biological Chemistry, 293(19), 7238-7249.