The basic requirements are below:
Your report should have the following major sections at minimum:
- Introduction and Rationale
- Background
- Include discussion on tissue engineering approaches and/or device(s)
- Clearly state the focus of this report
- Major milestones
- Discuss how findings, from a tissue engineering perspective, will advance medical science.
- Comment on how biology and/or physiology are important to the development of the approach/application.
- Summarize how the research results found in the literature articles show the potential of the solution and the impact on patient health.
- Methods
- Describe the critical experimental methods used in the literature articles you cite that are most relevant to understanding this thesis
- Describe the critical experimental models used for investigation in the literature articles you cite (in vitro, animal, human, etc.)
- Identify all the components/parts of the engineered solution and how they could be produced/obtained
- Important Protein Player
- Choose a protein that plays an important role in the function of your device/concept
- Explain what role the protein plays (ligand, receptor, etc.) and its general structure (alpha helix, beta sheet, multiple units, etc.)
- Explain how the protein functions in its role
- This protein can be an actual piece of the device, or it can be an endogenous protein that interacts with it.
- One Key Signaling Pathway
- Describe and diagram one key signaling pathway that is important to the functioning of your device/concept. It is acceptable to copy a diagram of the pathway from a book/drawing, as long as the diagram is cited.
- While Sections 5-6 may involve the same protein, describe the protein in Section 5 and the pathway in Section 6.
- Alternatively, you can describe a different signaling pathway here that does not involve the protein from Section 5.
- The pathway may be something the device directly interacts with, or it may be a pathway involved in the growth/regeneration/repair/genesis of the tissue type that interacts with your device.
- Important Cellular Interactions
- Describe and diagram one key intercellular interaction that is important to the functioning of your device/concept. It is acceptable to copy a diagram of the interaction from a book/drawing, as long as the diagram is cited.
- The interaction may relate to the Signaling Pathway in Section 6, or it may be an un-related separate interaction. If it is related, explain how the signaling pathway (which is intracellular) links up with the intercellular interaction.
- The cellular interaction may be something the device directly interacts with, or it may be an interaction involved in the growth/regeneration/repair/genesis of the tissue type that interacts with your device.
- Biocompatibility of the Device/Concept
- Conclude with how the engineered solution will provide the intended function.
- Include a discussion on the interactions of the Inflammatory and Immune systems. This could be a discussion on wound healing in general if that is the intent of the solution, or if the solution involves a surgical procedure that requires wound healing.
- Clearly identify the limitations of the research conclusions in regards to biocompatibility and patient health.
- Appendix
- Literature Search Keywords – Include all the keyword information from your literature search keyword assignment. Make sure it is updated and includes all new keywords used to revise/bolster your search. (If you changed nothing since your initial literature search, this is just a copy/paste of your literature search keywords. Be sure to update if you had corrections or additions.)
- Screening Log – Include the screening log from your literature keyword search assignment. Make sure it is updated and includes ALL articles from your final search and their rejection reasons, if applicable.
- Bibliography – Include all the articles you used in your report. It is not necessary to include articles in your bibliography that were rejected in your screening log.