History of diverticular disease

Case Scenario:
An 84- year-old -female who has a history of diverticular disease presents to the clinic with left lower quadrant (LLQ) pain of the abdomen that is accompanied by with constipation, nausea, vomiting and a low-grade fever (100.20 F) for 1 day.
On physical exam the patient appears unwell. She has signs of dehydration (pale mucosa, poor skin turgor with mild hypotension [90/60 mm Hg] and tachycardia [101 bpm]). The remainder of her exam is normal except for her abdomen where the NP notes a distended, round contour. Bowel sounds a faint and very hypoactive. She is tender to light palpation of the LLQ but without rebound tenderness. There is hyper-resonance of her abdomen to percussion.  
• The following diagnostics reveal:  
• Stool for occult blood is positive.
• Flat plate abdominal x-ray demonstrates a bowel-gas pattern consistent with an ileus. 
• Abdominal CT scan with contrast shows no evidence of a mass or abscess. Small bowel in distended. 
Based on the clinical presentation, physical exam and diagnostic findings, the patient is diagnosed with acute diverticulitis and she is admitted to the hospital. She is prescribed intravenous antibiotics and fluids (IVF). Her symptoms improved and she could tolerate a regular diet before she was discharged to home.   
Discussion Questions:

  1. Compare and contrast the pathophysiology between diverticular disease (diverticulosis) and diverticulitis.
  2. Identify the clinical findings from the case that supports a diagnosis of acute diverticulitis.  
  3. List 3 risk factors for acute diverticulitis.
  4. Discuss why antibiotics and IV fluids are indicated in this case.

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Sample Answer

 

1. Diverticular Disease vs. Diverticulitis:

Diverticular Disease (Diverticulosis):

  • Presence of small pouches (diverticula) on the inner lining of the colon.
  • Often asymptomatic or causes mild, non-specific symptoms like bloating or cramping.
  • Doesn’t necessarily progress to diverticulitis.

Diverticulitis:

  • Inflammation and infection of one or more diverticula.
  • More severe symptoms like abdominal pain, fever, nausea, and vomiting.
  • Can lead to complications like abscesses, fistulas, and bowel obstruction.

Similarities:

  • Both involve diverticula formation.
  • Share some risk factors like low fiber diet and older age.

 

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Differences:

  • Diverticulosis is asymptomatic or mildly symptomatic, while diverticulitis is acute and painful.
  • Diverticulosis doesn’t cause inflammation or infection, while diverticulitis does.

2. Clinical Findings Supporting Acute Diverticulitis:

  • LLQ abdominal pain
  • Constipation
  • Nausea and vomiting
  • Low-grade fever
  • Signs of dehydration
  • Distended abdomen with hypoactive bowel sounds
  • Tenderness on palpation in LLQ
  • Positive occult blood test (indicating possible bleeding)
  • Ileus pattern on X-ray

3. Risk Factors for Acute Diverticulitis:

  1. Low fiber diet: Fiber helps bulk up stool and reduce pressure in the colon, lowering the risk of diverticula formation and subsequent inflammation.
  2. Age: Risk increases significantly after 50 years old.
  3. Obesity: Puts additional pressure on the colon and increases risk of diverticula formation.
  4. Smoking: Damages blood vessels and tissues, hindering healing and increasing risk of complications.
  5. Antibiotics: Certain antibiotics may alter gut microbiota, potentially impacting diverticulosis and inflammation.
  6. Lack of physical activity: Sedentary lifestyle may contribute to constipation and increased pressure in the colon.

4. Rationale for Antibiotics and IV Fluids:

Antibiotics:

  • Target potential bacterial infection within the inflamed diverticula.
  • Aim to prevent further infection and promote healing.
  • Specific choice of antibiotics depends on individual factors and local resistance patterns.

IV Fluids:

  • Address dehydration caused by vomiting and lack of oral intake.
  • Maintain blood pressure and ensure adequate circulation.
  • Support healing and recovery by providing necessary hydration.

Additional Notes:

  • In this case, the CT scan did not show an abscess, suggesting uncomplicated diverticulitis, managed with conservative treatment (antibiotics and fluids).
  • For complicated cases with abscesses or other issues, additional interventions like drainage or surgery might be necessary.

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