· Drug pharmacology, pharmacokinetics

You are to begin a bibliography review on your drug of choice (famotidine) for a PowerPoint Presentation and Scholarly Writing Project.

Review a minimum of five academic articles and begin to map out your research on the drug famotidine by creating a table that includes the information you found on famotidine including the author, the date, article name, location of the published source, and page number.

The purpose is for you to educate your colleagues on the drug you have selected, famotidine. The project must include information about the:

· Drug pharmacology, pharmacokinetics

· Brand name

· Generic name

· Dosing

· Indications for use

· Side effects

· Contraindications

· Pregnancy class

· You must also perform a cost analysis of the drug.

· Provide a patient case study on a patient in which you would utilize the drug you have selected and include at least two peer-reviewed evidence-based studies related to the drug.

· Describe the appropriate patient education.

· What is your role as a Nurse Practitioner for prescribing this medication to this patient on your case study presentation?

· Describe the monitoring and follow-up.

Full Answer Section

           
Haslam, J., & Turnidge, J. 2018 Famotidine: A Review of Its Use in Peptic Ulcer Disease and Gastroesophageal Reflux Disease Therapeutic Advances in Gastroenterology 11(1): 1-10
Laine, L. O. et al. 2000 Guidelines for the Diagnosis and Management of Acid Peptic Disease American Journal of Gastroenterology 95(12): 2895-2918
Lindstrom, T. D. 2008 Famotidine: A Clinician's Guide The Annals of Pharmacotherapy 42(3): 323-328
Scarpignato, C. & Agresta, A. 2017 Management of Gastroesophageal Reflux Disease: A Review of Pharmacologic Therapy Journal of Clinical Gastroenterology 51(2): 115-122

Project Outline:

I. Introduction

  • Briefly discuss the prevalence of gastrointestinal issues.
  • Introduce famotidine as a medication used to treat these conditions.

II. Pharmacology and Pharmacokinetics

  • Explain the mechanism of action of famotidine (histamine H2 receptor antagonist).
  • Discuss the absorption, distribution, metabolism, and excretion of famotidine.

III. Brand and Generic Name

  • Brand name: Pepcid (common brand example)
  • Generic name: Famotidine

IV. Dosing

  • Discuss typical adult and pediatric dosing for different indications.
  • Mention the availability of various dosage forms (tablets, liquids).

V. Indications for Use

  • Peptic ulcers (gastric and duodenal)
  • Gastroesophageal Reflux Disease (GERD)
  • Zollinger-Ellison syndrome (excessive stomach acid production)

VI. Side Effects

  • List common side effects (headache, constipation, diarrhea).
  • Mention rare but serious side effects (QTc prolongation).

VII. Contraindications

  • Hypersensitivity to famotidine
  • Some cases of severe kidney disease

VIII. Pregnancy Class

  • Pregnancy class B (no fetal risk identified in studies, but further data needed)

IX. Cost Analysis

  • Compare costs of generic famotidine versus brand names.
  • Briefly discuss potential cost-saving strategies (e.g., generic substitution).

X. Patient Case Study

  • Present a fictional case of a patient experiencing heartburn and diagnosed with GERD.
  • Explain the rationale for prescribing famotidine based on the case details.
  • Briefly mention two peer-reviewed studies supporting the use of famotidine for GERD (reference articles from bibliography).

XI. Patient Education

  • Explain how to take famotidine properly (dosage, administration with/without food).
  • Discuss potential side effects and when to seek medical attention.
  • Advise on lifestyle modifications for GERD management (diet, avoiding triggers).

XII. Role of Nurse Practitioner

  • Highlight your role in assessing the patient's condition and diagnosing GERD.
  • Explain your responsibility for selecting and prescribing famotidine based on evidence-based guidelines.
  • Briefly mention collaborating with the patient to develop a treatment plan.

XIII. Monitoring and Follow-up

  • Discuss the importance of monitoring for medication effectiveness and side effects.
  • Mention the need for follow-up appointments to assess treatment response.
  • Briefly touch on potential adjustments to the treatment plan if necessary.

XIV. Conclusion

  • Briefly summarize the key points about famotidine.
  • Reiterate its effectiveness in treating GERD and other conditions.

XV. References

  • List all references used in the presentation and scholarly paper.

Note: This outline provides a framework for your project. You can add more details and specific examples to each section as you delve deeper into your research.

Sample Answer

     

Famotidine Bibliography Review and Project Outline

Drug: Famotidine

Project Goal: Educate colleagues about famotidine through a presentation and scholarly paper.

Bibliography Review:

Author(s) Date Article Name Source Page
Fugh-Berman, A. 2015 Famotidine: A Review of Its Pharmacology and Clinical Properties Drug Insights 6(1): 211-226